Linking signaling and selection in the germinal center
نویسندگان
چکیده
منابع مشابه
Defects in Germinal Center Selection in SLE
Germinal centers (GCs) are the primary site at which clonal expansion and affinity maturation of B cells occur. B cells encounter antigen and receive T cell help in the GC light zone (LZ) and then migrate to the dark zone where they proliferate and undergo somatic mutation before cycling back to the LZ for further rounds of selection. Tolerance to autoantigens is frequently lost de novo as GC B...
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ژورنال
عنوان ژورنال: Immunological Reviews
سال: 2019
ISSN: 0105-2896,1600-065X
DOI: 10.1111/imr.12744